Correlation of AFP with clinical pathological factors and prognosis of primary hepatic carcinoma
10.3760/cma.j.issn.1008-6315.2012.10.030
- VernacularTitle:甲胎蛋白与原发性肝癌临床病理因素及预后的相关性研究
- Author:
Jiang SU
;
Ke WANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Liver resection;
Alpha-fetoprotein;
Prognosis
- From:
Clinical Medicine of China
2012;28(10):1101-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of serum alpha-fetoprotein (AFP) with clinical pathological factors and prognosis of hepatocellular carcinoma ( HCC ).Methods Two hundred and twenty patients with HCC who hospitalized in our hospital from January 2007 to June 2009 were enrolled in this study.The relationship of AFP levels before operation to clinical pathological factors such as pathological grade,tumor size,tumor encapsulation,tumor numbers,portal vein tumor thrombus,TNM stage and postoperative recurrence were analyzed.Results Serum AFP concentration before operation were related with tumor size ( x2 =11.76,P ＜ 0.05 ),tumor encapsulation ( x2 =17.07,P ＜ 0.05 ),portal vein tumor thrombus ( x2 =8.944,P ＜ 0.05 ),higher TNM stage ( x2 =4.929,P ＜ 0.05 ) and early postoperative recurrence rate ( x2 =5.569,P ＜ 0.05 ).However,it had no correlation with pathological edmondson grade tumor numbers.Conclusion HCC patients with high serum AFP concentration often has greater tumor without encapsulation,high occurrence rate of portal vein tumor thrombus and higher TNM stage,they are more likely to early postoperative recurrence.Serum AFP before operation is useful not only for diagnosis,but also as a prognostic biomarker to predict prognosis and recurrence.
