The significance of peripheral blood CK19 mRNA expression in breast cancer patients
10.3760/cma.j.issn.1007-631X.2012.08.014
- VernacularTitle:乳腺癌患者外周血CK19 mRNA表达浓度监测的意义
- Author:
Yaxin ZHAO
;
Jiefan LIU
;
Zhongmin SUN
;
Minghua JIANG
;
Zhiqiang ZHENG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Keratins;
Prognosis;
Recurrence
- From:
Chinese Journal of General Surgery
2012;27(8):656-659
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the significance of CK19 mRNA monitoring in peripheral blood of breast cancer patients.MethodsPeripheral blood samples were collected from 137 breast cancer patients preoperatively,one day post-operation,7 days,1,3,6,12,18,and 24 months after operation.RTPCR was used to detect CK19 mRNA expression.The relationships were analyzed between CK19 mRNA expression and treatment result, between CK19 mRNA expression and clinicopathological parameters.ResultsThere was no significant difference between the level of CK19 mRNA as tested preoperatively,and 1,7 days postoperatively(P ＞ 0.05 ).From one month and thereafter,CK 19 mRNA decreased significantly when compared with that immediate perioperatives ( P ＜ 0.05 ). Postoperative peripheral CK19 mRNA expression increased in those found with recurrent or metastasized tumors ( P ＜ 0.01 ). CK19 mRNA expression does not correlate with patient's menstrual status,estrogen receptor expression,progesterone receptor expression,HER-2 expression and Ki67 proliferation expression (P ＞ 0.05 ). But there was statistically significant correlation between CK19 mRNA expression and tumour size,histology grading,pathological type,lymph node metastasis ( P ＜ 0.01 ).ConclusionsIn breast cancer patients peripheral blood CK19 mRNA expression is correlated with risk clinicopathological parameters, and increases in patients with postoperative recurrence and tumor metastasis.
