MYCN gene monitoring in children's malignant solid tumors
10.3760/cma.j.issn.1673-4408.2012.05.007
- VernacularTitle:MYCN基因监测在儿童恶性实体瘤中的临床研究进展
- Author:
Yiqiao CHEN
- Publication Type:Journal Article
- Keywords:
MYCN gene;
Solid tumors;
Neuroblastoma
- From:
International Journal of Pediatrics
2012;39(5):455-460
- CountryChina
- Language:Chinese
-
Abstract:
Although the incidence of malignant solid tumors in children is not high,it is one of the major death causes in children.MYCN gene amplification is an independent poor prognosis factor of neuroblastoma.MYCN gene involves in neuroblastoma tumorgenesis and is the major evidence of treatment.MYCN gene amplification could be detected in other children's solid tumor.It is associated with unfavorable medulloblastoma pathology,poor outcome of Wilms' tumor and alveolar rhabdomyosarcomas.This review compares different MYCN gene detection methods,makes a summary about the clinical relationship between MYCN gene and children's solid tumor and investigates the possibility of increasing cure rate of malignant solid tumors through molecular specificity treatment.
