Clinical significance of urinary biomarkers in early renal damage caused by ureteral obstruction
10.3760/cma.j.issn.1673-4408.2012.05.015
- VernacularTitle:尿生物标记物对输尿管梗阻致肾脏早期损伤的临床意义
- Author:
Yulong GONG
- Publication Type:Journal Article
- Keywords:
Ureteral obstruction;
Hydronephrosis;
Biomarker;
Children
- From:
International Journal of Pediatrics
2012;39(5):484-487
- CountryChina
- Language:Chinese
-
Abstract:
Urinary tract obstruction that occurs during early kidney development affects renal morphogenesis,maturation and growth,and in the most severe cases this will ultimately cause renal insufficiency.15％ ～ 20％ of the patients with obstructive nephropathy require early surgical intervention to preserve renal function,another part of those children without significant loss of renal function may be appropriate in conservative treatment because of spontaneous resolution.Current imaging examination for urethral obstruction are uncertainties and invasive,and therefore there is a need for urinary biomarkers that may be used as predictors for renal structural changes and decreasing renal function,and thereby provide the surgeon with more clear indications for surgical intervention.This review will discuss the clinical application value of various types of urinary biomarkers,including transforming growth factor-β1,monocyte chemoattractant protein-l,epidermal growth factor,endothelin-1,to provide important theoretical basis for searching new approaches for diagnosis,prevention and treatment of diseases related to ureteral obstruction and irreversible damage of kidney.
