Insulin-like growth factor binding protein 7 and tumors
10.3760/cma.j.issn.1673-4408.2012.05.021
- VernacularTitle:胰岛素样生长因子结合蛋白7与肿瘤
- Author:
Shuiyan WU
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor binding protein 7;
Tumor;
Signal transduction pathway
- From:
International Journal of Pediatrics
2012;39(5):503-506
- CountryChina
- Language:Chinese
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Abstract:
Insulin-like growth factor binding protein 7 exert modulatory function in insulin-like growth factor/insulin(IGF/INS) protein network by carrying and transiting IGF/INS,or prolonging their half-life.IGFBP7 has strong ability to bind insulin and low affinity to IGFs and plays a role in either IGFs-dependent way or IGFs-independent way.IGFBP7 involves in multiple function such as cell proliferation,adhesion,invasion,migration and tumor vascular formation through several signaling pathways.
