The relationship between serum cardiac troponin I and high sensitivity C-reactive protein, tumor necrosis factor-alpha in patients with acute organophosphorus pesticide poisoning and their clinical significance
10.3760/cma.j.issn.1673-4904.2012.27.005
- VernacularTitle:急性有机磷农药中毒患者血清心肌肌钙蛋白I与高敏C反应蛋白及肿瘤坏死因子α的关系及其临床意义
- Author:
Ruiguang GUO
;
Jiguo MIAO
;
Zhekun WANG
;
Yuantao LIU
;
Qinglong YAO
- Publication Type:Journal Article
- Keywords:
Heart injuries;
Systemic inflammatory response syndrome;
Acute organophosphorus pesticide poisoning
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(27):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum cardiac troponin I (cTnI) and high sensitivity C-reactive protein (hs-CRP),tumor necrosis factor-alpha (TNF-α ) in patients with acute organophosphorus pesticide poisoning (AOPP) and their clinical significance.Methods One hundred and twelve patients with AOPP (without sudden death ) were as AOPP group.One hundred and twelve healthy controls were as control group.Serum cTnI,hs-CRP and TNF-α levels were determined by ELISA and compared between two groups.The relationship between serum cTnI and hs-CRP,TNF-α was analyzed.Time for atropinization and acetylcholinesterase activity recovery and days of hospitalization were observed.The effectiveness of AOPP patients in different serum cTnI levels was compared.Results Serum cTnI,hs-CRP and TNF- α levels in AOPP group[0.75 (0.26,0.99) μ g/L,11.57(5.13,21.62) mg/L,( 12.36 ±5.22) μ g/L] were higher than those in control group[0.01 (0,0.03) μ g/L,3.62(2.31,6.80) mg/L,(7.33 ±4.31 ) μ g/L] (P ＜ 0.01 ).Serum cTnI levels were positive correlation with serum hs-CRP and TNF- α levels in AOPP patients (r =0.53,0.62,P ＜ 0.01 ).Time for atropinization and acetylcholinesterase activity recovery and days of hospitalization in higher serum cTnI levels patients ( 56 cases ) [(7.31 ± 1.96),( 15.29 ± 3.66 ),(17.23 ± 3.62) d] was longer than that in lower serum cTnI levels patients (56 cases)[(5.32 ± 1.03),( 11.32 ± 2.59),( 13.66 ± 3.03) d](P＜ 0.01).Conclusions Cardiac insults in AOPP patients are related to inflammation.Sudden death-free AOPP patients with higher cTnI levels have less response to treatments.
