The influence of fluvastatin on the levels of IL-6 ,MMP-1 and APN in patients with coronary heart diseases
10.3760/cma.j.issn.1008-6706.2012.20.008
- VernacularTitle:氟伐他汀对冠心病患者白细胞介素-6、基质金属蛋白酶-1和脂联素水平的影响
- Author:
Jingyi LYU
;
Hongxia LI
- Publication Type:Journal Article
- Keywords:
Coronary heart diseases;
Interleukin-6;
Matrixmetalloproteinase-1;
APN;
Fluvastatin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(20):3054-3055
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the influence of fluvastatin on the levels of IL-6,MMP-1 and APN in patients with coronary heart diseases.Methods60 patients with coronary heart diseases were randomly divided into 2groups:40mg group and 80mg group treated by fluvastatin and 30 healthy persons were selected as control group,serum levels of IL-6,MMP-1 and APN were measured before and after treatmead.ResultsSerum levels of IL-6,MMP-1 were significantly increasd in the coronary heart diseases group (t =4.896,4.231,all P ＜ 0.05 ).Serum level of APN was significantly decreasd in the coronary heart diseases group( t =4.352,P ＜ 0.05 ).The serum levels of IL-6and M MP-1 were significantly decreasd after therapy (4.156,4.121、4.553,all P ＜ 0.05 ).The decrease of serum levels of IL-6,MMP-1 in 80mg group was more significant than those of 40mg group( t =3.786,3.690,4.10,all P ＜0.05).ConclusionSerum concentrations of IL-6 and MMP-1 increase,but APN decrease in patients with coronary heart diseases.Serum concentrations of IL-6,MMP-1 and APN had relationships with coronary plaque extent.Fluvastatin could decrease serum levels of IL-6 and MMP-1,increase serum level of APN in patients with coronary heart diseases,and have a beneficial effect on steadying the plaque.
