MicroRNA-19 and neoplasms
10.3760/cma.j.issn.1673-422X.2012.09.001
- VernacularTitle:miR-19与肿瘤
- Author:
Jikui SUN
;
Zhifan JIA
;
Weidong YANG
- Publication Type:Journal Article
- Keywords:
miR-19;
Neoplasms;
Lymphoma;
Leukemia
- From:
Journal of International Oncology
2012;39(9):643-646
- CountryChina
- Language:Chinese
-
Abstract:
The miR-17-92 cluster,consisting of six individual microRNAs,including miR-17,miR-20a,miR-18a,miR-19a,miR-19b and miR-92a-1,is a kind of typical oncogenic polycistron microRNA.MiR-19 (containing miR-19a and miR-19b),as the key oncogenic component in miR-17-92 cluster,is overexpressed in human cancers including lymphomas,leukaemia,lung cancer,breast cancer and multiple myeloma,and has been one of research focus in recent years.It is found that miR-19 promotes tumor growth,invasion and metastasis through negative regulation of target genes such as PTEN,PP2A,Bim,SOCS1,and is correlated strongly with PI3K-AKT-mTOR pathway.MiR-19 plays an important role in tumor genesis and development.