Telosome: biological function and its relationship with tumor
10.3760/cma.j.issn.1673-422X.2012.09.004
- VernacularTitle:端粒结合蛋白复合体的生物功能及其与肿瘤发生的关系
- Author:
Yixian GUO
;
Wanling SUN
;
Changqing XIA
- Publication Type:Journal Article
- Keywords:
Telomere;
Telomere-binding proteins;
Neoplasms
- From:
Journal of International Oncology
2012;39(9):654-658
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies show that the structure integrality and function are more important than the length of telomere in maintaining tumor cells reproduction and proliferation.Mammalian telomeres bound by a specialized six-protein(TRF1,TRF2,TIN2,RAP1,POT1 and TPP1 )complex known as telosome or shelterin,has fundamental role in the regulation of telomere activity,maintaining the length and protecting telomere chromosome terminal.Telosome is involved in the complex regulation of cell mitosis process.The study of the role of telomere binding protein complex in tumorigenesis is very important for searching new methods of tumor diagnosis and treatment.
