The CpG island methylator phenotype in hepatocellular carcinoma research progress
10.3760/cma.j.issn.1007-8118.2012.10.023
- VernacularTitle:肝细胞癌的CpG岛甲基化表型研究进展
- Author:
Zhiyun ZHENG
;
Lin ZHOU
;
Shusen ZHENG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
CpG island;
Methylation;
Phenotype
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(10):799-802
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC) is one of the most common devastating neoplasms worldwide with very poor prognosis.Recent studies have identified a CpG is land methylator phenotype(CIMP),which was characterized by simultaneous methylation of multiple TSGs.CIMP has been observed in multiple human malignant tumors including HCC.CIMP also plays a critical role in HCC carcinogenesis,progression,metastasis and recurrence. Therefore,detection of the methylation status of tumor-related genes can provide key information for early diagnosis,molecular classification and predicting prognosis of HCC.
