Analysis on the major risk factors of elderly type 2 diabetes mellitus complicated by coronary heart disease
10.3760/cma.j.issn.0254-9026.2012.04.006
- VernacularTitle:老年2型糖尿病患者并发冠心病的危险因素分析
- Author:
Lixin GUO
;
Jing MA
;
Yang CHENG
;
Lina ZHANG
;
Qi PAN
;
Xiaoxia WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Coronary disease;
Principal component analysis;
Albuminuria
- From:
Chinese Journal of Geriatrics
2012;31(4):286-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the major risk factors of elderly type 2 diabetes mellitus (T2DM) complexing with coronary heart disease(CHD) via principal component analysis (PCA).Methods The clinical data of 503 subjects aged ＞ 60 years with T2DM were retrospectively analyzed.Urinary albumin excretion rate(UAER) from urine collected from 10:00 PM to 6:00 AM was measured by chemiluminescence.The degree of angiostegnosis was evaluated by Judkins coronary arteriography and Gensini score. According to UAER level, the patients were divided into microaibuminuria group (20 mg/L＜UAER＜200 mg/L,n= 226) and normal urinary albumin group (UAER＜20 mag/L,n=277).PCA was used to discuss the major risk factors to affect T2DM patients with CHD in the elderly. Results Characteristic values of the principal component from first to seventh were all more than 1,their cumulative rate was 64.7％. The first to fourth principal components and their variances were UAER(14.1％),blood fat (11.8％),blood pressure(10.2％)and uric acid( 8.7 ％),respectively.The fifth to seventh principal components were all blood glucose and the cumulative variance was 19.8％.The numbers of angiostegnosis were 36.5G％ single,34.7％double and 28.9 ％ three in patients with normal urinary albumin,while1(10.2％) single,27.9％ doubleand 61.9％ three in patients with microalbuminuria,respectively(P＜0.05).The Gensini scores was increased in microalbuminuria group (50.7± 35.8) as compared with normal urinary albumin group (19.74±23.0) (P＜0.05). UAER was independently related to Gensini scores (β=0.442,P=0.000). Conclusions UAER is the most important factor of elderly T2DM complexing with CHD and positively correlated with severity of CHD as its independent factor.
