Comparision of sedative effect between propofol and midazolam in elderly patients with craniocerebral trauma
10.3760/cma.j.issn.0254-9026.2012.04.011
- VernacularTitle:丙泊酚和咪达唑仑对老年颅脑损伤患者镇静效果的比较研究
- Publication Type:Journal Article
- Keywords:
Craniocerebral trama;
Conscious sedation;
Intensive care
- From:
Chinese Journal of Geriatrics
2012;31(4):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the sedative effect between propofol and midazolam in the aged with traumatic brain injury and undergoing mechanical ventilation in intensive care unit(ICU).Methods Totally 76 cases with traumatic brain injury undergoing mechanical ventilation in ICU were divided into two groups:propofol and midazolam groups(n=38 for each group).The incidence rates of hypotension and bradycardia,the time course in ICU,the percentage of satisfactory sedation time,the average time of neurological assessment,duration from ICU arrival to off,the time of diastasis and tube drawing were compared between the two groups. Results The incidence rate of hypotension and bradycardia were higher in propofol group than in midazolam group [15.8%(6/38),13.2% (5/38)vs.2.6%(1/38),0% (0/38),x2 =3.93,5.35,P=0.047,0.021]. The time of treatment,diastasis,tube drawing and neurological assessment during ICU were shorter in propofol group than in midazolam group[(105.2±16.9)h,(3.5±0.3) h,(1.06±0.03) h and (1.12±0.(03) h vs.(112.2±30.5)h,(5.5±0.4) h,(1.34±0.03) hand (1.41±0.06)h,t=6.35,12.45,20.01,13.43,all P<0.05].There were no differences in the duration from ICU arrival to off and the percentage of satisfactory sedation time between the two groups[(74.6±16.5) h and (97.6±1.3)% vs.(75.3±12.5)hand(97.2±1.8)%,t=1.07,0.57,both P>0.05]. Conclusions Propofol and midazolam are safe and effective for sedation in the aged patients with traumatic brain injury.Midazolam is better in hemodynamics effects than propofol,while propofol outgoes midazolam in the time of diastasis and tube drawing.