Clinical control study of ondansetron, metoclopramide and haloperidol in the prevention of postoperative nausea and vomiting after neurosurgery
10.3760/cma.j.issn.1673-4904.2012.15.003
- VernacularTitle:昂丹司琼、甲氧氯普安和氟哌利多预防神经外科手术后患者恶心呕吐的临床对照研究
- Author:
Weifang PEI
;
Yuping LI
;
Guiyu WANG
- Publication Type:Journal Article
- Keywords:
Postoperative nausea and vomiting;
Ondansetron;
Metoclopramide;
Haloperidol
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(15):8-10
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical difference of ondansetron,metoclopramide and haloperidol in the prevention of postoperative nausea and vomiting after neurosurgery.MethodsNinety patients with neurosurgery were divided by random digits table method into four groups:control group ( 18 cases ) treated with 10 ml 0.9％ sodium chloride ;ondansetron group(24cases ) received ondansetron 4 mg;metoclopramide group (24 cases) with metoclopramide 10 mg and haioperidol group (24 cases) with haloperidol 2.5 mg.The efficacy and adverse reaction were compared among four groups.Results Compared with control group,ondansetron,metoclopramide and haloperidol could obviously inhibit the occurrence of postoperative nausea and vomiting after neurosurgery,the difference had statistical significance (P＜ 0.05).Total effective rate of ondansetron group [79.2％( 19/24)] was significantly higher than that of metoclopramide group [ 58.3％ ( 14/24 ) ] and haloperidol group [ 54.2％ ( 13/24 ) ] (P ＜ 0.05 ).And total effective rate of metoclopramide group and haloperidol group had no significant difference (P ＞ 0.05 ).The occurrence rate of adverse reaction of metoclopramide group [ 16.7％(4/24)] had no statistical significance compared with that of ondansetron group[8.3％(2/24)] and haloperidol group[ 12.5％(3/24)] (P ＞ 0.05).ConclusionsOndansetron,metoclopramide and haloperidol can obviously inhibit the occurrence of postoperative nausea and vomiting after neurosurgery,and the effect of ondansetron is significantly better than that of metoclopramide and haloperidol.Therefore,it is necessary to use drugs for preventing postoperative nausea and vomiting for patients during neurosurgery.
