The effect and safety analysis of arsenic trioxide combined with all-trans retinoic acid in treating patients with acute promyelocytic leukemia
10.3760/cma.j.issn.1673-4904.2012.13.012
- VernacularTitle:三氧化二砷联合全反式维A酸治疗急性早幼粒细胞白血病疗效与安全性分析
- Author:
Qingyu REN
;
Keyu ZHAO
;
Fulian LIU
;
Sufang CHEN
;
Zhenxing WANG
;
Jingmin YU
;
Shufang PEI
- Publication Type:Journal Article
- Keywords:
Leukemia,promyelocytic,acute;
Tretinoin;
Arsenic trioxide
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(13):34-36
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect and safety of arsenic trioxide (ATO) combined with all-trans retinoic acid (ATRA) in treating patients with acute promyelocytic leukemia (APL).Methods Eighty-three cases with APL treated for the first time were divided into two groups by random digits table method:observation group with 48 cases was received combination induction treatment of ATO and ATRA,control group with 35 cases was treated with combination induction treatment of ATRA and chemotherapy.The clinical effect and adverse reaction between two groups were compared.ResultsThe effective rate and early death rate were 100.0％( 48/48 ) and 0 in observation group,97.1％(34/35 ) and 2.9％( 1/35 ) in control group,which had no significant difference between two groups(P ＞ 0.05 ).The incidences of bone marrow suppression,infection,liver and kidney damage,cardiac toxicity and gastrointestinal symptoms were 8.3％ (4/48),10.4％ (5/48),12.5％ (6/48),6.2％ (3/48) and 18.8％ (9/48) in observation group,while 97.1％(34/35),65.7％(23/35),45.7％(16/35),37.1％(13/35) and 100.0％(35/35) in control group,which had significant differences between two groups (P ＜ 0.05).ConclusionCombination treatment of ATO and ATRA in APL has an obvious effect and few adverse reaction,which can be applied in clinic.
