Expression and clinical significance of interleukin-6 and interleukin-17 in patients with chronic rhinosinusitis
10.3760/cma.j.issn.1673-4904.2012.15.007
- VernacularTitle:白细胞介素6和白细胞介素17在慢性鼻-鼻窦炎患者血浆中的表达及其临床意义
- Author:
Feng LI
- Publication Type:Journal Article
- Keywords:
Sinusitis;
Interleukin-6;
Interleukin-17
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(15):19-21
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the expression of interleukin-6 (IL-6) and interleukin-17 (IL-17) in patients with chronic rhinosinusitis (CRS),and analyze the effects of IL-6 and IL-17 on the occurrence and development of CRS.MethodsSelected 200 CRS patients who planned to receive operation treatment,including 36 cases with type Ⅰ,139 cases with type Ⅱ and 25 cases with type Ⅲ,and they were chosen as CRS group and divided into nasal polyps group ( 109 cases) who had nasal polyps and no nasal polyps group (91 cases) who didn't have nasal polyps.And 50 healthy subjects were chosen as control group.The plasma IL-6 and IL-17 concentration were detected by double-antibody sandwich ELISA method.ResultsThe plasma IL-6 and IL-17 levels of CRS group were (13.23 ±5.94),(9.24 ±4.15) ng/L respectively,significantly higher than those of control group[ (2.26 ± 1.01 ),( 1.58 ± 0.71 ) ng/L] (P ＜ 0.05 ),there was no significant difference between nasal polyps group and no nasal polyps group (P ＞ 0.05 ).The plasma IL-6 levels in type Ⅰ, Ⅱ and Ⅲ were(4.54 ±2.04),(12.90 ±5.80),(27.42 ± 12.32) ng/L respectively,and IL-17 levels were (3.17 ± 1.42),(9.01 ± 4.05),( 19.15 ± 8.61 ) ng/L,there were statistical differences among different clinical types (P ＜ 0.05).The plasma IL-6 and IL-17 level of CRS patients had significantly positive correlation (r =0.519,P ＜ 0.05).ConclusionsThe IL-6 and IL-17 expression are closely relatcd to the occurrence and development of CRS.
