The correlation study between rs3093059 of C-reactive protein and ischemic stroke
10.3760/cma.j.issn.1673-4904.2012.13.006
- VernacularTitle:C反应蛋白rs3093059位点与缺血性脑卒中的相关性研究
- Author:
Xinyun LIU
;
Xiaoping LI
;
Yan LIU
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Cerebrovascular accident;
Genes;
rs3093059
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(13):17-19
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the correlation between rs3093059 in single nucleotide polymorphism (SNP) of C-reactive protein (CRP) and ischemic stroke (IS).MethodsOne hundred and twenty-eight patients with IS were selected as observation group and 112 individuals without atherosclerotic vascular disease were recruited as control group.Genotype of rs3093059 in SNP of CRP in two groups determined by polymerase chain reaction-restrictive fragment length polymorphism(PCR-RFLP) were compared.The risk factors of IS were analyzed by multi-factor non-conditional Logistic regression model.ResultsThe distribution of genotype and allele frequency of rs3093059 in two groups conformed to Hardy-Weinberg balance test (P ＞ 0.05).It showed that all the cases belonged to the same population.Observation group comparing with control group,genotypes (GG 90 cases vs.94 cases,GC 18 cases vs.3cases,CC 20 cases vs.15 cases),allele frequency (G allele 198 cases vs.191 cases,C allele 58 cases vs.33cases) and dominant model distribution(CC + GC 108 cases vs.97 cases,CC 20 cases vs.15 cases) of rs3093059 had no significant difference (P＞ 0.05).But negative model distribution (CC + GC 38 cases vs.18 cases,GG 90 cases vs.94 cases) of rs3093059 had statistical significance (P ＜ 0.05).According to multi-factor non-conditional Logistic regression model analysis,the male sex,history of hypertension,diabetes and smoking,and negative model of rs3093059 were independent risk factors of IS (P ＜ 0.05).Conclusion The negative model of rs3093059 is an independent risk factor of IS.
