Clinical value of detecting vascular endothelial growth factor in sputum of patients with pulmonary arterial hypertension associated with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1673-4904.2012.13.009
- VernacularTitle:血管内皮生长因子在慢性阻塞性肺疾病肺动脉高压痰液中的检测及临床意义
- Author:
Yuanhua WANG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Hypertension,pulmonary;
Vascular endothelial growth factor A
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(13):26-28
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the changes and clinical significance of vascular endothelial growth factor (VEGF) in sputum of patients with pulmonary arterial hypertension associated with chronic obstructive pulmonary disease (COPD).MethodsThe sputum VEGF levels of 52 cases with pulmonary arterial hypertension associated with COPD during stable period (group A),60 cases with COPD during stable period (group B) and 50 normal persons (group C) were detected by enzyme linked immunosorbent assay (ELISA)method.The pulmonary function,arterial blood gas analysis and pulmonary artery systolic pressure (PASP)were detected.ResultsThe sputum VEGF levels of group A,B and C were (4.30±0.93),(2.64±0.57)and ( 1.48±0.32 ) μ g/L respectively,which had significant difference ( F =31.612,P ＜ 0.01 ).The percentage of forced expiratory volume in the first second (FEV1) in predicted value (FEV1％) of group A,B and C were (48.68±10.53 )％,(67.56±14.61 )％,( 101.60±21.97 )％ respectively,which had significant difference (F =28.983,P ＜ 0.01 ),as well as PASP had [ (55.02±11.90),(23.50±5.08 ),(16.16±3.49) mm Hg (1 mm Hg =0.133 kPa),F=34.887,P＜ 0.01 ].The arterial partial pressure of oxygen (PaO2) and carbon dioxide(PaCO2) of three groups had no significant difference (F=2.159,3.167,P ＞ 0.05).The sputum VEGF level had significantly negative correlation with FEV1％ (r =-0.562,P ＜ 0.05),and positive correlation with PASP(r =0.783,P＜0.05),while had no correlation with PaO2,PaCO2(r =-0.318,0.275,P＞0.05).ConclusionsThe sputum VEGF level of patients with pulmonary arterial hypertension associated with COPD expresses high level,which has significant correlation with pulmonary function and PASP.Therefore,VEGF plays an important role in the pathogenesis of pulmonary arterial hypertension associated with COPD.
