The effect of butylphthalide on plasma brain-type creatine kinase isoenzyme,endothelin and calcitonin gene related peptide in patients with acute cerebral infarction
10.3760/cma.j.issn.1673-4904.2012.13.011
- VernacularTitle:丁苯酞对急性脑梗死患者血浆脑型肌酸激酶同工酶、内皮素及降钙素基因相关肽的影响
- Author:
Qunli LIN
;
Wandong XU
;
Dongbo YANG
;
Shenghao ZHENG
;
Congcong HU
;
Hongyan LIN
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Creatine kinase,BB form;
Endothelial cells;
Butylphthalide
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(13):31-33
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the correlation between butylphthalide and plasma brain-type creatine kinase isoenzyme (CK-BB),endothelin (ET),calcitonin gene related peptide (CGRP) in patients with acute cerebral infarction (ACI).MethodsSixty patients with ACI were divided into treatment group and control group with 30 cases each by random digits table method.Both groups received normal treatment continuously for 7 days,and butylphthalide of 200 mg was added to treatment group for 3 times per day.The levels of plasma CK-BB,ET and CGRP of two groups before and after treatment were measured and compared.ResultsThe levels of plasma CK-BB,ET of two groups both decreased significantly after treatment,but CGRP rose obviously.It showed significant differences before and after treatment of both groups (P ＜0.01 or ＜ 0.05).The levels of plasma CK-BB,ET of treatment group after treatment were lower than those of control group in the same period [(216.48±36.95) U/L vs.(333.07±54.03) U/L,(83.33±26.48)ng/L vs.(98.46±31.46) ng/L,P ＜ 0.05 ].The level of plasma CGRP of treatment group after treatment was significantly higher than that of control group in the same period [ (44.16±13.28 ) ng/L vs.(36.42±12.31 )ng/L,P ＜ 0.05 ].ConclusionButylphthalide can reduce the plasma enzyme activity,balance ET and CGRP,extend the cerebral arteries to antagonize ET,improve cerebral ischemia and cerebral hypoxia,which can protect brain cells and endothelial cells.
