The effect of montelukast combined with loratadine on serum interferon -γ and interleukin- 4 in children suffered from cough variant asthma
10.3760/cma.j.issn.1673-4904.2012.10.005
- VernacularTitle:孟鲁司特联合氯雷他定对小儿咳嗽变异型哮喘血清干扰素γ和白细胞介素4的影响
- Author:
Xuemei HAN
;
Wenhua WANG
- Publication Type:Journal Article
- Keywords:
Asthma;
Montelukast;
Loratadine
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(10):13-14
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the change of serum interferon- γ(IFN- γ ) and interleukin-4(IL-4)level in children suffered from cough variant asthma after montelukast combined with loratadine therapy.MethodsForty-six patients of children cough variant asthma were recruited and accepted montelukast combined with loratadine therapy for 8 weeks.The changes of serum IFN-γ and IL-4 before and after therapy were compared.ResultsCompared with before therapy,the level of serum IFN- γwas decreased [ (59.94 ± 9.43) ng/L vs.(39.94 ± 9.07) ng/L ] and IL-4 was increased[ ( 48.78 ± 22.23 ) ng/L vs.(60.78 ±16.48) ng/L] after therapy,there were significant differences (P ＜0.05).ConclusionMontelukast combined with loratadine in the treatment of children cough variant asthma can improve the balance of IFN- γ/IL-4,which deserve further study.
