Efficacy and safety of intratympanic methylprednisolone perfusion treatment of refractory sudden deafness
10.3760/cma.j.issn.1673-4904.2012.12.009
- VernacularTitle:经耳道鼓室置管灌注甲泼尼龙治疗难治性突发性聋的安全性和有效性
- Author:
Feng LI
- Publication Type:Journal Article
- Keywords:
Deafness;
Ear,middle;
Methylprednisolone
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(12):23-26
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the efficacy and safety of intratympanic methylprednisolone perfusion treatment of refractory sudden deafness.MethodsSixty-eight cases of refractory sudden deafness were recruited and divided by random digits table method into intratympanic-treatment group(34 cases)treating with intratympanic methylprednisolone perfusion and control group (34 cases)accepting methylprednisolone intravenous infusion treatment.The curative effect,adverse reaction of two groups were compared and the factors that effected intratympanic perfusion treatment were analyzed.ResultsEight cases of intratympanic-treatment group were cured,twelve cases were markedly effective,nine cases were effective and five cases were ineffective; while seven cases of control group were cured,five were markedly effective,seven were effective and fifteen were ineffective.The total efficiency of intratympanic-treatment group compared with that of control group showed significant difference[ 85.3％(29/34) vs.55.9％ (19/34),P ＜ 0.01 ].Improvement value of impaired frequency examined by pure tone audiometry(PTA) of intratympanic-treatment group was higher than that of control group [ ( 18.0 ± 16.2) dB vs.(8.2 ± 9.8) dB,P ＜ 0.05 ].In intratympanic-treatment group,improvement value of impaired frequency of patients whose age was lower than 50 and disease course was shorter than one month was higher than that of patients whose age was higher than 50 and disease course was longer than one month(P ＜ 0.01 ).The complication rate of intratympanic-treatment group was 8.8％(3/34),and no case had complications such as further decline in hearing.ConclusionThe intratympanic methylprednisolone perfusion treatment is safe and effective for refractory sudden deafness,and deserves further improvement and widely promotion.
