Feasibility and clinical effect comparison of bispectral index monitoring target controlled infusion of midazolam and propofol for sedation of mechanically ventilated patients
10.3760/cma.j.issn.1673-4904.2012.09.002
- VernacularTitle:脑电双频指数监测下靶控输注咪达唑仑和丙泊酚对机械通气患者镇静的可行性及临床效果比较
- Author:
Ying ZHOU
;
Xuezheng ZHANG
;
Bin DING
;
Yupeng XIE
;
Xuru JIN
- Publication Type:Journal Article
- Keywords:
Target controlled infusion;
Mechanical ventilation;
Sedation;
Bispectral index
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(9):4-7
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the feasibility and clinical effect of bispectral index (BIS) monitoring target controlled infusion of midazolam and propofol for sedation of mechanically ventilated patients.MethodsEighty cases with severe respiratory failure,sane,the need for endotracheal intubation mechanical ventilation for at least 24 h were divided into 4 groups by random digits table with 20 cases each.Group A and group C patients routinely received propofol and midazolam,group B and group D patients used BIS monitoring target controlled infusion of propofol and midazolam.The correlation of BIS and Ramsay score was analyzed,and the changes of mean arterial pressure (MAP) and heart rate (HR) were compared among 4 groups.ResultsBIS was negatively correlated with Ramsay score in group B and group D (P ＜ 0.05).MAP after 24 h intubation was lower than that at intubation immediately among 4 groups [group A:(63.89 ±4.68) mm Hg (1 mm Hg =0.133 kPa) vs.(92.33 ±3.57) mm Hg,group B:(62.66 ±3.97) mm Hg vs.(93.76 ± 4.02) mm Hg,group C:(64.59 ± 3.29) mm Hg vs. (93.78 ± 4.61 ) mm Hg,group D:(63.18 ±2.51 )mm Hg vs. (93.61 ± 5.36) mm Hg],and there were significant differences (P＜ 0.05).Group A and group B reached the standard after 1 h intubation.HR after 24 h intubation decreased in 4 groups,but there was no significant difference (P ＞ 0.05).ConclusionsBIS monitoring target conmolled infusion of midazolam and propofol for sedation of mechanically ventilated patients can achieve similar sedative effects,in addition,the need for rapid sedation of mechanically ventilated patients with suitable choice of propofol.At the same time,BIS is negatively correlated with Ramsay score.
