The changes of IL-17 and inflammatory corpuscle percentage in the induced phlegm from the children with bronchial asthma
10.3760/cma.j.issn.1673-4408.2012.03.030
- VernacularTitle:不同严重程度支气管哮喘儿童诱导痰IL-17含量及炎症细胞百分比变化
- Author:
Chao MA
;
Shaomin REN
;
Chunzhi LIU
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Induced phlegm;
Interleukin17;
Inflammatory cells
- From:
International Journal of Pediatrics
2012;39(3):316-318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of IL-17 and neutrophils,eosinophils percentage in the induced phlegm from the children with different severity bronchial asthma.Methods Forty children with acute asthma were divided into two groups according to the severity of asthma:medium or severe group(n =16) and light group( n =24 ).Twenty normal children were chosen in the same stage as control group.The IL-17 content and the percentage of neutrophils and eosinophils were compared.Results The contents of IL-17 in the medium or severe group,light group and control group were(1.096 ±0.664) ng/L,(0.474 ±0.240) ng/L and(0.227 ±0.360 ) ng/L respectively.The percentage of neutrophils were ( 55.359 ± 12.486 ) ％,( 44.476 ± 17.708 ) ％ and ( 36.493 ± 12.470 ) ％ respectively.The percentage of eosinophils were ( 1.252 ± 2.025 ) ％,(4.107 ± 3.234) ％and (1.409 ± 3.480) ％ respectively.There were significant differences in three groups ( P ＜ 0.05 ).There was significant positive correlation between IL-17 content and percentage of neutrophils in the medium or severe group( r =0.740,P =0.049 ).There was negative correlation in the light group ( r =- 0.764,P =0.000 ).Conclusion There was different among IL-17 content and percentage of neutrophils,eosinophils in children of different groups.The study showed that IL-17 was involved in the potential pathogenesis of asthma.
