Correlation of levels of serum Hcy and MMP-9 with carotid intima-media thickness in patients with essential hypertension
10.3760/cma.j.issn.1008-6706.2012.11.009
- VernacularTitle:原发性高血压患者血清半胱氨酸、基质金属蛋白酶-9水平变化及其与颈动脉内膜中层厚度的相关性研究
- Author:
Yan YANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Hyperhomocysteinemia;
Matrix metalloproteinase-9;
Intima-media thickness
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(11):1618-1619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of levels of Hyperhomocysteinemia (Hcy) and Matrix metalloproteinase-9(MMP-9) with intima-media thickness (IMT) in patients with essential hypertension (EH).Methods 100 cases with EH and 30 healthy control subjects were selected.The levels of serum Hcy and MMP-9 were detected by enzyme-linked immunosorbent assay(ELISA).The IMT was detected by high-resolution ultrasound which as a index of large vessels atherosclerosis.Results The levels of serum Hcy and MMP-9 in EH group were significantly higher than those in control group( t =4.52,4.78,4.19,all P ＜ 0.05 ).With the increased level of blood pressure classification IMT progressively thicker,and carotid atherosclerosis extent gradually increased,Hcy and MMP-9 increased significantly.The levels of Hcy and MMP-9 were significantly higher showed significant diference( all P ＜0.05 ) ; the levels of serum Hcy and MMP-9 were positively correlated with IMT ( r =0.352,0.326,all P ＜ 0.05 ).Conclusion The levels of serum Hey and MMP-9 rere positively correlated with IMT in EH patients,and it suggested that Hcy and MMP-9 participate the pathological process of arteriosclerosis.
