Expression and clinical significance of epidermal growth factor receptor and vascular endothelial growth factor in non-small cell lung cancer
10.3760/cma.i.issn.1008-6706.2012.11.017
- VernacularTitle:表皮生长因子受体及血管内皮生长因子在非小细胞肺癌组织中的表达
- Author:
Xianhui DAI
;
Handong JIANG
- Publication Type:Journal Article
- Keywords:
Cancer,non-small cell lung;
Immunohistochemistry;
Receptor,epidermal growth factor;
Vascular endothelial growth factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(11):1634-1636
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of epidermal growth factor receptor(EGFR) and vascular endothelial growth factor(VEGF) in non-small cell lung cancer(NSCLC) and the reletionship with clinic-pathologic parameters.Methods Immunohistochemistry of tissue sections was used to study the expression of EGFR and VEGF in 124 NSCLC tissues and 15 normal lung tissues adjacent to cancer tissues.Results The positive rates of EGFR and VEGF in 124 NSCLC samples were 52.4％,66.1％,while no expressed in the 15 normal lung tissues adjacent to cancer tissues.The positive rate of VEGF with stage Ⅲ was higher than that with stage Ⅰ - Ⅱ ( 80.4％ vs 56.2％,P ＜0.05).The positive rate of VEGF with lymph node metastasis was higher than that without lymph node metastasis (78,2％ vs 53.3％,P ＜ 0.05 ).The expression of VEGF and EGFR had no relationship with clinic pathological factors including histological type of lung cancer,sex,age.EGFR and VEGF expression was statistically correlated with each other( r =0.93,P ＜0.05 ).Conclusion EGFR and VEGF were overexpressed in NSCLC tissues.The expression of VEGF was correlated with TNM stages and lymph node metastasis.The expression of EGFR was correlated with VEGF expression in NSCLC tissues,which indicates they might act synergistically in angiogenesis of NSCLC.
