Escitalopram combined with aripiprazole in the treatment of 46 patients with obsessive compulsive disorder
10.3760/cma.j.issn.1008-6706.2012.07.008
- VernacularTitle:艾司西酞普兰联合阿立哌唑治疗强迫症46例
- Author:
Hongsheng CHEN
- Publication Type:Journal Article
- Keywords:
Escitalopram;
Aripiprazole;
Compulsive personality disorder;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(7):976-977
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe and explore the clinical efficacy and safety of escitalopram combined with aripiprazole in the treatment of obsessive-compulsive disorder.Methods97 patients with obsessive-compulsive disorder were randomly divided into two groups,control group of 51 patients were given oral administration of escitalopram treatment,46 patients in the experimental group received escitalopram and oral aripiprazole treatment.At the end of treatment,the clinical efficacy and adverse events were evaluated.ResultsIn control group and experimental group patients overall effective rate was 68.6％,89.1％ ;The experimental group the total effective rate was higher than the control group,the difference between two groups was statistically significant( x2 =12.32,P ＜0.05 ),The control group and experimental group after treatment Y-BOCS scores were (23.68 ± 2.74 ) points,( 21.82 ± 2.88 ) points ; The experimental group after treatment Y-BOCS score was significantly better than the control group,between the two groups the difference was statistically significant ( t =2.64,P ＜ 0.05 ) ; While after treatment the TESS score and incidence of adverse reactions between the two groups were not statistically different ( t =0.61 ; x2 =0.03,all P ＞ 0.05 ).ConclusionEscitalopram combined with aripiprazole in the treatment of obsessive compulsive disorder obtain excellent effect,had few adverse reactions,and was worthy of clinical application.
