Clinical analysis of methotrexate combined with mifepristone in the treatment of unruptured ectopic pregnancy

VernacularTitle:甲氨蝶呤联合米非司酮治疗未破裂型输卵管妊娠的临床分析
Author: Jian ZHANG ; Hongxia LI ; Wenjing ZHANG
Publication Type:Journal Article
Keywords: Pregnancy,tubal; Methotrexate; Mifepristone
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(7):981-982
CountryChina
Language:Chinese
Abstract: ObjectiveTo observe the clinical effect of methotrexate combined with mifepristone in the treatment of unruptured ectopic pregnancy.Methods96 cases of unruptured ectopic pregnancy patients were randomly classified into two groups,observation group with 48 cases was treated with methotrexate combined with mifepristone and control group with 48 cases was only treated with methotrexate.The treatment effect and adverse reaction between two groups were compared.ResultsThe time of blood β-HCG recovery to normal and hospitalization time in observation group were significantly shorter than those in control group( P ＜ 0.05 ),and mass diameter was significantly smaller than that in control group( P ＜ 0.05 ).The adverse reaction incidence in observation group was 10.4％ ( 5/48 )while 6.3％ (3/48) in control group.ConclusionMethotrexate combined with mifepristone in the treatment of unruptured ectopic pregnancy could enhance clinical effect,shorten treatment time,decrease adverse reaction,which could be applied in clinic.