Clinical research of single glucocorticoid treatment and glucocorticoid joint cyclophosphamide treatment on thyroid-associated ophthalmopathy

VernacularTitle:糖皮质激素单药及联合环磷酰胺治疗甲状腺相关眼病的临床研究
Author: Shuhui YANG ; Xianru SHEN ; Huan WENG
Publication Type:Journal Article
Keywords: Graves ophthalmopathy; Glucocorticoids; Cyclophosphamide
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(7):966-967
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the effect of single glucocorticoid treatment and glucocorticoid joint cyclophosphamide treatment on thyroid-associated ophthalmopathy.MethodsRetrospective analysis of clinical data of 35patients used single glucocorticoid( single medicine group) and 16 patients used glucocorticoids joint cyclophosphamide(joint group) was carried out.ResultsThe effective rate of joint group(93.8％ ) was significantly higher than single drug group (68.6％) ( x2 =3.87,P ＜ 0.05).Simple using glucocorticoid had significant treatment effect at CAS score,prominent eyes degrees,soft tissue inflammation score,but the curative effect was significantly lower than the joint group ( P ＜ 0.05 ).The adverse reaction rate had no significant difference between two groups.ConclusionCompared to single glucocorticoid treatment,the glucocorticoid joint cyclophosphamide treatment had better effect and lower adverse reaction rate,especially suitable for patients who had no effect or low effect on hormone therapy.