Measurement and clinical significance of IL-8 、IL-13 and IL-18 in serum of patients with bronchial asthma

VernacularTitle:支气管哮喘患者血清白细胞介素8、13、18水平的变化及意义
Author: Fuqiang LI
Publication Type:Journal Article
Keywords: Asthma; Interleukin-8; Interleukin-13; Interleukin-18
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(7):983-984
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the change and significance of IL-8,IL-13 and IL-18 level in serum of patients with bronchial asthma.Methods45 patients with acute exacerbation of bronchial asthma were selected (acute group),and remission group 45 patients and 30 healthy persons (control group) were selected.The serum IL-8,IL-13 and IL-18 levels were measured respectively by ELISA.ResultsThe serum IL-8,IL-13 and IL-18 levels in acute group were significantly higher than that in control group and remission group ( t =5.21,5.13,4.99,5.32,5.48,5.59,P ＜ 0.05 ) ; The serum IL-8,IL-13 and IL-18 levels in remission group were significantly higher than that in control group(t =4.18,4.71,4.89,P ＜0.05).ConclusionThe levels of serum IL-8,IL-13 and IL-18 may be related to the severity of asthma attack.IL-8,IL-13 and IL-18 played important role in both pathogenesis and determination of asthma.