Efficacy and safety of ibutilide for conversion of atrial fibrillation
10.3760/cma.j.issn.1008-6706.2012.07.017
- VernacularTitle:伊布利特转复心房颤动的疗效及安全性评价
- Author:
Ning SHEN
- Publication Type:Journal Article
- Keywords:
Atrial fibrillation;
Ibutilide;
Amiodarone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(7):995-996
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy and safety of ibutilide for conversion of paroxysmal and persistent atrial fibrillation.Methods31 patients with atrial fibrillation duration less than 90 days were included into amiodrone or ibutilide group.16 patients were intravenously administer with amiodrone and 15 patients with ibutilide separately.Conversion rate,time needed to converse and adverse effects were compared between two groups.ResultsThe total conversion rate of ibutilide group was significantly higher than that of amiodrone group (66.7% vs 37.5%,x2 =1.98,P < 0.05 ).Time needed to converse was significantly shortened in ibutilide group compared with amiodrone group [ ( 31.75 ± 7.39 ) min vs ( 51.87 ± 9.26 ) min,t =3.67,P < 0.05 ].No clinical significant adverse effects were observed in ibutilide group.ConclusionIntravenous administration of ibutilide in cardioversion of paroxysmal and persistent atrial fibrillation was more safe and effective than amiodrone.