Clinical significance of TGF-β1 and VEGF expression in tissues of nasal inverted papilloma
10.3760/cma.j.issn.1008-6706.2012.07.013
- VernacularTitle:转化生长因子-β1和血管内皮生长因子在鼻腔鼻窦内翻转乳头状瘤组织中的表达
- Author:
Jun YANG
;
Fucun SONG
;
Zhiyuan ZHOU
;
Xiaowen CHAI
- Publication Type:Journal Article
- Keywords:
Paranasal sinus diseases;
Papilloma,inverted;
Transforming growth factor betal;
Vascular endothelial growth factor A
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(7):987-988
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical significance of transforming growth factor β1 (TGF-β1)and vascular endothelial growth factor (VEGF) expression in tissues of nasal inverted papilloma (NIP).MethodsThe clinical data of patients with NIP underwent surgical resection were retrospectively analyzed.The TGF-β1 and VEGF expression in NIP tissues and nasal polyps tissues were detected by immunohistochemistry method.100 patients with NIP were divided into benign lesions,atypical hyperplasia and malignant group according to result of pathological diagnosis,the nasal polyps was used as the control group.ResultsThe positive expression rate of TGF-β1 and VEGF in the NIP group were 46.0％ and 32.0％,compared with the control group the differences were significant(all P ＜ 0.05 ).In different pathological groups,the results of TGF-β1 and VEGF expression were malignant group ＞ atypical hyperplasia ＞ benign lesions.The positive expression rate of TGF-β1 and VEGF in the NIP group had significantly positive correlation(P ＜ 0.05).ConclusionThe TGF-β1 and VEGF expression were closely related to the the occurrence,development and malignant of NIP.TGF-β1 was highly expressed in the NIP tissues,and could increase the expression of VEGF and promote the formation of neovascularization of NIP.
