Expression and the role of intercellular adhesion molecule-1 in the occurrence and development of hepatoma
10.3760/cma.j.issn.1673-4203.2012.05.015
- VernacularTitle:细胞间黏附分子-1在肝癌发生发展中的表达及作用
- Author:
Xiwen ZHU
;
Lang BAI
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
Intercellular adhesion molecule- 1;
NF- κB signal transduction pathways;
Liver cancer/hepatocellular carcinoma;
Inflammation
- From:
International Journal of Surgery
2012;39(5):336-339
- CountryChina
- Language:Chinese
-
Abstract:
Intercellular adhesion molecule -1 is closely related to the occurrence,development and me mastasis of liver cancer.A variety of inflammatory cytokines and stimulus effect on the expression of Intereclluar adhesion molecule-1 through Nuclear factor-kappa B signal transduction pathways.In the stage of inflammation,hepatocirrhusis and tumor,Intercelluar adhesion molecule-1 is expressed differently,and makes different effects on different cells,to promote the occurrence and metastasis of tumor.Diagnostic significance of Intercelluar adhesion molecule1 is to diagnose hepatocellular carcinoma with AFP-negative or suspected-positive more early.What's more it can prognosticate the metastasis and prognosis of liver cancer as a biomarker.Many new treatments of liver cancer are based on the effects on Intercelluar adhesion molecule-1 in different levels producing antitumor function.
