Vascular Diseases Associated with Protein C and/or S Deficiencies.
- Author:
Yong Pil CHO
1
;
Deok Hee LEE
;
Seung Mun JUNG
;
Hyuk Jai JANG
;
Jee Soo KIM
;
Myoung Sik HAN
Author Information
1. Department of Surgery, Asan Kangnung Hospital, Kangnung, Korea.
- Publication Type:Case Report
- Keywords:
Protein C and S deficiencies;
Hypercoagulable state;
Vascular diseases
- MeSH:
Diagnosis;
Heparin;
Humans;
Prognosis;
Prospective Studies;
Protein C*;
Risk Factors;
Serologic Tests;
Vascular Diseases*;
Venous Thrombosis;
Warfarin
- From:Journal of the Korean Surgical Society
2002;62(2):181-186
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: There are a number of conditions that can lead to a hypercoagulable state, however, protein C and S deficiencies are frequently described as causes of the hypercoagulable states. The aim of this study was to evaluate the clinical features and prognosis of vascular diseases associated with protein C and/or S deficiencies and to determine an adequate treatment modality for such cases. METHODS: We prospectively evaluated 7 cases with vascular disease caused by protein C and/or S deficiencies confirmed with serologic tests. RESULTS: Four patients showed venous thrombosis, 1 peripheral arterial insufficiency, 1 cerebral venous thrombosis and peripheral arterial insufficiency, and 1 portal vein thrombosis. Surgical intervention was required in 5 patients. Full anticoagulation with heparin sodium followed by warfarin sodium was done in all patients. CONCLUSION: Protein C and S deficiencies may influence clinical management. Patients presenting with atypical vascular involvement without evidence of other risk factors should be evaluated for a hypercoagulable state. Once the diagnosis is made, patients should be treated with full anticoagulation.
