Effects of Qingjinkangkuoyin on TNF-α and NE in lung tissue of rats with bronchiectasis
10.3760/cma.j.issn.1673-4246.2012.04.009
- VernacularTitle:清金抗扩饮对支气管扩张模型大鼠的白细胞、中性粒细胞及其弹性蛋白酶作用探讨
- Author:
Jun TANG
;
Libo ZHEN
;
Hua QIAN
;
Xiaobo LING
;
Jianwu CHEN
- Publication Type:Journal Article
- Keywords:
Bronchiectasis;
Qingjinkangkuoyin;
TNF-α;
NE
- From:
International Journal of Traditional Chinese Medicine
2012;34(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Qingjinkangkuoyin (QJKKY) on TNF-α and NE in rats with bronchiectasis.Methods Models were established by intrabronchially injecting with pseudomonas aeruginosa,and divided into 5 groups by random:the QJKKY high dose treatment group (given high dose of QJKKY into stomach),the QJKKY low dose treatment group (given low dose of QJKKY),the levofloxacin group (given levofloxacin),the model group (given normal saline),and the normal contrast group (given normal saline).After 2 weeks of treatment,the histopathology of lung tissue,the levels of TNF-α and inflammatory cells in peripheral blood and NE in rats' lung tissue were detected.Results Compared with the model group (160.425±9.9293)ng/L,QJKKY could decrease the level of TNF-α in blood significantly [high dose of QJKKY treatment group was (137.133±6.1646)ng/L,P＜0.05]; the expression of inflammatory cells in serum were decreased significantly by QJKKY [high dose of QJKKY treatment group was (1.106± 0.3580) 109/L,P＜0.05].Low dose of QJKKY treatment group was (1.086 ±0.2433) 109/L,(P＜0.05) ; the expression of NE in lung tissue were decreased remarkably by QJKKY [high dose of QJKKY treatment group(80.697 ±4.5877)ng/L,P＜0.05]; low dose of QJKKY treatment group is (80.747±3.6925)ng/L,(P＜0.05); and the histopathologic change of lung tissue in QJKKY treatment groups were ameliorated under light microscope by HE staining.Conclusion Qingjinkangkuoyin could cure bronchiectasis by decreasing the expression of TNF-αin peripheral blood and NE in rats' lung tissue.
