The effects of COE on the expression of VEGF and CECs of Hepal-6 tumor bearing mice
10.3760/cma.j.issn.1673-4246.2012.04.011
- VernacularTitle:南蛇藤总萜对Hepal-6荷瘤小鼠VEGF、CECs的影响
- Author:
Ying HOU
;
Chunlan NIE
;
Yanqing LIU
- Publication Type:Journal Article
- Keywords:
Celastrus orbiculatus;
Angiogenesis;
CECs;
VEGF
- From:
International Journal of Traditional Chinese Medicine
2012;34(4):324-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of Celastrus orbiculatus extracts (COE) on the expression of VEGF and CECs of Hepal-6 tumor bearing mice.Methods Animal Models of Hepal-6 portability liver tumor bearing mice were established and randomly assigned to six groups (eight mice per group) as follows:untreated control group,solvent vehicle control (DMSO) group,physiological saline control group,cisplatin-treated group,and different dosages COE-treated groups (40 mg/kg,20 mg/kg,10 mg/kg).To approach the effects of COE on the expression of VEGF and CECs in Hepal-6 toumor bearing mice.Results The ELISA and flow cytometer showed that COE could significantly inhibit the expression of VEGF(45.24±21.36) pg/ml and CECs (0.83 ± 0.10) ％ compared with the physiological saline control group (P＜ 0.01 ) with the dose of 20mg/kg.Conclusion COE could significantly down-regulate the expression of VEGF and CECs.It may be related with the effect of COE in inhibiting angiogenesis of tumor.
