The relationship between extravascular lung water and the prognosis of sepsis acute lung injury/acute respiratory distress syndrome: a Meta analysis

VernacularTitle:血管外肺水与脓毒症相关性ALI/ARDS预后关系的Meta分析
Author: Du CHEN ; Shiqi LU ; Feng XU ; Wei LI
Publication Type:Journal Article
Keywords: Extravascular lung water; Sepsis; Shock; Acute lung injury; Acute rcspiratory distress syndrome; Prognosis; Risk factor; Meta analysis
From: Chinese Journal of Emergency Medicine 2012;21(4):375-378
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of extravascular lung water (EVLW) in predicting the prognosis of sepsis acute lung injury (ALI) / acute respiratory distress syndrome (ARDS).Methods Relevant published articles concerned with EVLW both in Chinese and in English from 1991-2011 were searched,and Meta-analysis was carried out with Stata software. Results Seven articles were selected for Meta-analysis according to the inclusion and exclusion criteria.The results indicated EVLW of dead patients group kept in a high level,while EVLW showed a down-trend in the survival group.The difference in level of EVLW between the two groups became more obvious with the day ( SMDd1＜ SMDd2 ＜ SMDd3 ) ( the 1st day:SMDd1=0.29,95％CI:0.047-0.532; the2nd day:SMDd2=1.64,95％CI:0.14-3.13; the 3rd day:SMDd3 =1.83,95％ CI:0.56-3.10).Conclusions EVLW and its dynamic change in the early stage of sepsis ALI/ARDS could predict the prognosis.This suggested the sustained high level would lead to high mortality.