Effects of the indoleamine 2,3- dioxygenase- initiated L- tryptophan metabolism in organ transplantation
10.3760/cma.j.issn.1673-4203.2012.03.016
- VernacularTitle:吲哚胺-2,3-双加氧酶介导的色氨酸代谢在器官移植中的作用
- Author:
Yonggang XU
;
Junming XU
- Publication Type:Journal Article
- Keywords:
Indoleamine 2,3- dioxygenase;
Tryptophan;
Immune tolerance;
Organ transplantation
- From:
International Journal of Surgery
2012;39(5):339-342
- CountryChina
- Language:Chinese
-
Abstract:
Tryptophan is the essential amino acid in the growth of cell.Indoleamine 2,3-dioxygenase is the rate-limiting enzyme in the catabolism of tryptophan along the kynurenine pathway.Indoleamine 2,3-dioxygenase enzyme mainly promotes tryptophan consumption of local micro-environment,causing tryptophan lack,thus inhibiting proliferation and activation of T cell.Tryptophan-derived catabolites suppress allogeneic T-cell proliferation (kynurenine,3-hydroxykynurenine,and 3-hydroxyanthranilate).Indoleamine 2,3-dioxygenase dendritic cells may interact with regulatory T cells forming an immunomodulatory network to promote immune tolerance induction.Though the immune regulation mechanism of the indoleamine 2,3-dioxygenase-initiated L-tryptophan in transplantation remains unclear,Numerous researches indicate that its role of tolerance induction in transplantation will be significant.
