The role and significance of T-helper cell subtypes in the pathoaenesis of rheumatoid arthritis

VernacularTitle:Th17/调节性T细胞在类风湿关节炎中的作用及其意义
Author: Junwei CHEN ; Shaoran ZHANG ; Chenglan YAN ; Jianfang XIE ; Zhiqin LV ; Jing LUO ; Xiaofeng LI
Publication Type:Journal Article
Keywords: Arthritis,rheumatoid; Th1 cells; T-helper cell subtypes
From: Chinese Journal of Rheumatology 2012;16(4):229-232
CountryChina
Language:Chinese
Abstract: Objective To explore the correlation between Th1,Th2,Th17,and Treg cells differentiation and related cytokines in patients with rheumatoid arthritis (RA).Methods Seventy-one patients with active RA were enrolled in this study.They were divided into low,moderate and high disease activity groups according to disease activity score (DAS28).The frequencies of Th1,Th2,Th17,and Treg cells in the peripheral blood of RA patients group (n=71) and healthy conlrol group (n=18) were determined by flow cytometry.T test was used for statistical analysis.Results Significant difference could be detected between the proportions of Th1 [ (6.2±4.5)％],Th17 [ (1.1±0.9)％] and Treg [(1.8±1.2)％] cells in the peripheral blood of RA patients and the control group (P＜0.05),and there was correlation between proportions of these three kinds of cell and the DAS28.Conclusion Th1 and Th 17 cells may promote the development of RA disease,but Th2 and Treg cells could prevent further development of RA disease.