Clearance effect of hemodiafihration and hemoperfusion combined with hemodialysis on serum calcium, phosphorus and parathyroid hormone in patients with uremia
10.3760/cma.j.issn.1008-6315.2012.05.020
- VernacularTitle:血液透析滤过和血液灌流联合血液透析对尿毒症患者血清钙磷及甲状旁腺激素清除的影响
- Author:
Lijun CHEN
- Publication Type:Journal Article
- Keywords:
Henodialysis;
Hemoperfusion;
Hemodiafihration;
Parathyroid hormone;
Serum calcium;
Serum phosphorus
- From:
Clinical Medicine of China
2012;28(5):511-514
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clearance effect of hemodiafihration(HDF) and hemopeffusion combined with hemodialysis( HP + HD) on serum calcium,phosphorus and parathyroid hormone in patients with uremia.Methods Fifty-eight uremia patients treated with maintenance hemodialysis in our hospital from May 2009 to October 2010 were randomly divided into two groups:HDF group (n =29)and HP + HD group (n =29).Patients in HP + HD group underwent HD conventional treatment 5 times and HP + HD.treatment once every two weeks,while those in HDF group underwent HD treatment 5 times and HDF treatment once every two weeks.All subjects were treated for 12 weeks.Serum calcium,phosphorus and parathyroid hormone were detected and analyzed before and after the treatment.Results After therapy,the serum calcium ( [ 2.41 ± 0.32 ] mmol/L v.s.[ 2.22 ± 0.35 ] mmol/L,t =5.47,P ＜ 0.01 ),phosphorus( [ 1.98 ± 0.34 ] mmol/L v.s.[ 1.70 ± 0.31 ] mmol/L,t=8.13,P ＜0.01)and parathyroid hormone( [645.19 ± 184.52] ng/L v.s.[296.79 ± 103.54]ng/L,t =6.54,P ＜ 0.01 ) levels of HP + HD group decreased significantly.Similarly,the serum calcium ( [ 2.43 ± 0.33 ] mmol/ L v.s.[ 2.32 ± 0.37] mmol/L,t =6.72,P ＜ 0.01 ),phosphorus ( [ 1.97 ± 0.36 ] mmol/L v.s.[ 1.83 ± 0.35 ] mmol/L,t =6.47,P ＜ 0.01 ) and parathyroid hormone ( [ 639.47 ± 208.73 ] ng/L v.s.[ 409.91 ± 152.72 ] ng/L,t =5.27,P ＜ 0.01 ) levels of HDF group also decreased significantly.Comparison of the two blood purification methods indicated that the clearance effect of HP + HD on serum calcium,phosphorus and parathyroid hormone was significantly better than HDF( t =4.24 and t =7.24,P ＜ 0.01 ).Conclusion Both HDF and HD + HP could clear serum calcium,phosphorus and parathyroid hormone effectively,while the clearance effect of HD +HP is better than HDF.
