Relationship between interleukin-1β-511C/T polymorphism and susceptibility to gout in Chinese male population
10.3760/cma.j.issn.1007-7480.2012.04.012
- VernacularTitle:中国沿海地区汉族男性人群白细胞介素-1β-511C/T基因多态性与痛风的易感性研究
- Author:
Congcong YIN
;
Shan REN
;
Yingchun ZHAO
;
Changgui LI
;
Wei REN
;
Shiguo LIU
- Publication Type:Journal Article
- Keywords:
Imterleukin 1;
Polymorphism,single nucleotide;
Gout;
HAN nationality
- From:
Chinese Journal of Rheumatology
2012;16(4):264-267
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore gene polymorphism of the C/T genotype of rs 16 944 in the promoter of IL-1β gene in male population living in the coastal area of Shandong,and thus to investigate the relationship between the gene polymorphism of IL-1β and gout.Methods A total of 276 gout patients and 268 healthy controls were enrolled.The possible association between the polymorphism of IL-1β-511 C/T and gout in Chinese was investigated and gcnotype frequencies and allelic frequencies were calculated by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method.Hardy-Weinberg was used to verify the representativeness of the sample.Comparisons between the groups were performed with x2 test and t-test.Results There was no statistically difference in IL-1β-511 C/T genotype frequencies between gout patients and controls(x2=3.251,P=0.197,df=2).The allele frequencies of C and T in gout cases were not different from those in the controls (x2=2.941,P=0.086,OR=1.232,95％CI:0.971-1.563).Moreover,no association between IL-1β-511C/T genotypes and risk factors for gout were observed in gout cases by x2 test.Conclusion Results of the present study suggest that the C/T genotype of rs 16944 in the promoter of IL-1β gene is not associated with gout in male population living in the coastal area of Shandong.
