The impact of bone marrow megakaryocyte to clinical and immunological characteristics of thrombocytopenia in systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2012.04.007
- VernacularTitle:血小板减少的系统性红斑狼疮患者骨髓巨核细胞量与临床特点的关系
- Author:
Xu LIU
;
Yuan JIA
;
Yunshan ZHOU
;
Limin REN
;
Xuewu ZHANG
;
Yin SU
;
Zhanguo LI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Thrombocytopenia;
Megakaryocyte;
Disease activity
- From:
Chinese Journal of Rheumatology
2012;16(4):243-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance.of thrombocytopenia in systemic lupus erythematosus (SLE).Methods One hundred and two SLE patients with thrombocytopenia who were admitted to Peking University People's Hospital were involved in the study.SLE patients without thrombocytopenia were controls.Clinical and laboratory characteristics were analyzed.T-test and Chi-square test were used for inter-group comparison.Results Patients with thrombocytopenia had more organ damage than those without,although the disease activities (SLEDAI) were not different between these two groups.Bone marrow characteristics were analyzed and 16 patients were amegakaryocytic.However,there were no differences observed between patients with amegakaryocytosis and normal megakaryocytes in organ damage,disease activity and response to therapy.Conclusion Lupus patients with thrombocytopenia usually have more organ damage.About 32％ of those patients are amegakaryocytosis.
