The treatment and prognosis of anaplastic thyroid carcinoma

VernacularTitle:甲状腺未分化癌108例的治疗和预后分析
Author: Tingting XIA ; Xiangqian ZHENG ; Jing ZHAO ; Yang YU ; Songfeng WEI ; Yigong LI ; Ming GAO
Publication Type:Journal Article
Keywords: Thyroid neoplasms; Prognosis; Therapy
From: Chinese Journal of General Surgery 2012;27(4):282-285
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the clinical biocharacteristics,treatment,prognosis and the factors that influence prognosis of anaplastic thyroid carcinoma(ATC). MethodsThe clinical data of 108 ATC patients treated at our institution from January 1981 to April 2009 and follow-up results were retrospectively reviewed.ResultsThe median survival time of 108 patients was 6 months.The overall 1-year,2-year,5-year survival rate was 40.3％,30.9％ and 21.9％ respectively.Univariate analysis showed the factors influencing the prognosis of ATC patients were tumor size, distant metastases, stage,leukocytosis, radiotherapy, localresection, postoperativeradiotherapyandmultimodalitytherapy.Multivariate analysis indicated that tumor size,stage,leukocytosis and radiotherapy were independently associated with the prognosis.ConclusionsAnaplastic thyroid carcinoma is rare but highly aggressive malignancy with poor prognosis. ATC patients should receive multimodality therapy,especially local resection and postoperative radiotherapy.Even inoperable patients could benefit from radiotherapy.