The clinical efficacy and safety of intravenous cefmetazon for prevention of postoperative infections and treatment of infectioons in general surgery
10.3760/cma.j.issn.1007-631X.2012.04.011
- VernacularTitle:注射用头孢美唑钠预防术后感染及治疗普外科感染的有效性与安全性评价
- Author:
Lin ZHONG
;
Zhengjun QIU
;
Guoqing CHEN
;
Junming XU
;
Xing SUN
;
Tonghai XING
;
Zhaowen WANG
;
Junwei FAN
;
Shuyun WANG
;
Li HUANG
;
Jinyan ZHANG
;
Zhihai PENG
- Publication Type:Journal Article
- Keywords:
Cefmetazole;
Antibiotic prophylaxis;
Bacterial infections;
Treatment outcome
- From:
Chinese Journal of General Surgery
2012;27(4):295-298
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the clinical efficiency and safety of cefmetazon in the prevention Department of General Surgery,First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,Chinaand or treatment of infections in general surgery. MethodsA multicenter,prospective and open-labeled trial was conducted. In the prevention group,1700 patients were enrolled in clean-infection surgery,cefmetazon was given 1 g iv half an hour before the surgery started,and 1 g iv twice daily after the surgery for 3 days.Clinical response was evaluated in terms of both cure ( disappearance of pre treatment symptoms)and pathogen. In the treatment group,897 patients were diagnosed as peritonitis, cholecystitis and cholangitis,the patients were given cefmetazon 2 g iv twice a day for 7 - 14 days,clinical response and microbiological efficacy were assessed.ResultsIn prophylactic group,1449 patients were finally included.The clinical efficacy was 100％ (1449/1449).In the treatment group,a total of 897 patients were enrolled,and 110 patients failed for assessment of clinical efficacy,787 patients were included in the PPS population,the clinical efficacy was 90.7％ (714/787); Bacterial eradication rate was 92％ (46/50).Adverse reaction rates in prevention group and treatment group were 1.3％ (22/1700) and 1.2％ (11/897),including mild nausea and vomitting.ConclusionsCefmetazon is effective and safe in prevention and treatment of Postoperative infections in general surgery.
