Chemerin in hepatocelluar carcinoma: expressions and prognostic values
10.3760/cma.j.issn.1007-8118.2012.04.013
- VernacularTitle:Chemerin在肝细胞肝癌中的表达及其预后价值
- Author:
Zhaoxiang YU
;
Yinghui CHEN
;
Qingguang LIU
- Publication Type:Journal Article
- Keywords:
Chemerin;
Hepatocellular carcinoma;
Prognosis
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(4):283-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of Chemerin in hepatocellular carcinoma (HCC) and HCC cell lines,and to demonstrate the relationship between the expressions and prognosis.Methods The expressions of Chemerin protein in normal hepatocellular tissues,HCC and their paired tissues were detected by immunohistochemical staining of SABC; the expressions of Chemerin protein in HCC,cell lines and immortalized hepatocyte cell lines were detected by RT-PCR.Results The positive expression rates of Chemerin were 56.67％,90.00％,100％ in HCC,HCC cell line and normal hepatocellular tissues respectively,and the differences were significant (P＜0.05).The expressions of Chemerin mRNA in HCC paired tissues were higher than in HCC (P＜0.05).There was a higher expression of Chemerin mRNA in immortalized hepatocyte cell line LO2 ; but a lower expression in HCC cell lines.The expressions of Chemerin were related to lymph node metastasis,portal vein tumour thrombi,differentiation and TNM stage but not related to sex,age,tumour size,HBsAg and AFP.Conclusions Down-regulated expression of Chemerin may play an important role in the development,progression and metastasis of HCC.It may be a molecular marker for prognosis of HCC.
