Metabolic phenotype and cardiovascular risk factors in the first degree relatives of Chinese women with polycystic ovary syndrome
10.3760/cma.j.issn.1000-6699.2012.04.016
- VernacularTitle:多囊卵巢综合征患者一级亲属代谢表型及心血管疾病风险的分析
- Author:
Tao TAO
;
Wei LIU
;
Aimin ZHAO
;
Xiuying MAO
;
Jiejin YANG
;
Jiawen ZHOU
- Publication Type:Journal Article
- Keywords:
Polycystic ovarian syndrome;
First degree relatives;
Insulin resistance;
Cardiovascular disease
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(4):315-318
- CountryChina
- Language:Chinese
-
Abstract:
To test the hypothesis that the first degree relatives of Chinese women with polycystic ovarian syndrome (PCOS) have higher risk of cardiovascular disease than those without PCOS.The metabolic phenotype and risks of cardiovascular disease were evaluated in 110 family members of 35 women with PCOS and 85 unrelated healthy control subjects without family history of diabetes and PCOS ( four age- and weight-matched subgroups ).The prevalence of impaired glucose tolerance was 51.4％ in mothers and 57.5％ in fathers with their daughters suffering from PCOS.The first degree relatives of PCOS women had significantly higher serum fasting insulin level,homeostasis model assessment for insulin resistance,insulin area under the curve,and lower insulin sensitivity index in all subgroups than the control subjects( P＜0.05 ).The control subjects had significantly elevated high molecular weight-adiponectin levels and decreased high sensitive-C reactive protein levels compared to the first degree relatives of PCOS women in all subgroups.Parents and brothers,but not sisters,of women with PCOS had significantly higher total cholesterol and low density lipoprotein-cholesterol ( P＜ 0.05 ),as well as triglyceride levels ( P＜ 0.05 ),compared with control subjects.The first degree relatives of PCOS women had features of insulin resistance and increased risk of cardiovascular disease.
