Study on relationship among expression of IGF-1 in peri-hematomal brain region,excessive and depletion syndrome of stroke after cerebral hemorrhage
10.3760/cma.j.issn.1673-4246.2012.03.005
- VernacularTitle:脑出血后胰岛素样生长因子-1表达与中风闭、脱证关系的研究
- Author:
Lili GAO
;
Chenghan WU
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage;
Insulin-like growth factor-1;
Excessive syndrome;
Depletion syndrome
- From:
International Journal of Traditional Chinese Medicine
2012;34(3):207-209
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of IGF-1 in the peri-hematomal brain region of Intracerebral Hemorrhage(ICH) patients,and to investigate the relationship among IGF-1,excessive and depletion syndrome of stroke.Methods 28 patients were evenly and randomly recruited into 3groups:Yin excessive group,Yang excessive group and depletion group.Additional 6 persons of normal death within 3 hours were taken their brain tissue.The IGF-1 expression was detected with Western blotting method.The correlation among the expression of IGF-1,excessive and depletion syndromes were observed.Results The expression of IGF-1 in the peri-hematomal brain region of ICH patients significantly increased in comparison with the normal control group (P=0.00).The expression of IGF-1 was significantly different among Yang excessive,Yin excessive and the depletion syndromes [ (0.696±0.111)、(1.151 ±0.185)、(1.697±0.108),P＜0.01],with the expression of IGF-1 of depletion syndrome ranked the highest,followed by Yin excessive and Yang excessive syndrome.Conclusion The expression of IGF-1 could reflect the degree of brain impairment.
