Short-term acute rejection incidence of recipients under the steroid-free immunosuppressive therapy after liver transplantation
10.3760/cma.j.issn.0254-1785.2012.04.007
- VernacularTitle:无皮质激素的免疫抑制方案对肝移植后近期急性排斥反应发生率的影响
- Author:
Tianyu XING
;
Qiang XIA
;
Qigen LI
;
Ning XU
;
Lei XIA
;
Longzhi HAN
;
Conghuan SHEN
;
Zhifeng XI
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Immunosuppressive agents;
Glucocorticoids;
Graft rejection
- From:
Chinese Journal of Organ Transplantation
2012;33(4):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the short-term acute rejection incidence of the recipients under the steroid-free immunosuppressive therapy after liver transplantation. Methods This retrospective study included 186 patients who were divided into two groups by random number table.The patients in no steroid group (the study group, n =94) received tacrolimus (Tac) with mycophemolate mofetil (MMF) or cyclosporine with MMF,and those in the steroid group (the control group,n =92) received the aforementioned immunosuppressive therapy combined with steroids.The acute rejection incidence was analyzed during six months post-transplantation.Results There was no significant difference in the gender,age,indication for transplantation,Child-Pugh score,MELD score,operating time,bleeding and transfusion volume during the operation,warm ischemia time and cold ischemia time between the two groups (P＞0.05).Liver biopsy was done on 9 cases of each group.The acute rejection incidence had no significant difference between the study group and the control group (5/94 vs 4/92,5.3％ vs 4.4％,P＞0.05).Conclusion The steroid-free immunosuppressive therapy after liver transplantation did not increase the short term acute rejection incidence.
