Clinical value of multi-slice spiral CT before lung transplantation in patients with IPF associated with pulmonary arterial hypertension
10.3760/cma.j.issn.0254-1785.2012.04.010
- VernacularTitle:特发性肺间质纤维化伴肺动脉高压患者肺移植前应用多层螺旋CT的价值
- Author:
Ying CHEN
;
Jingyu CHEN
- Publication Type:Journal Article
- Keywords:
Pulmonary fibrosis;
Hypertension,pulmonary;
Tomography,spiral computed;
Lung transplantation
- From:
Chinese Journal of Organ Transplantation
2012;33(4):229-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss MSCT assessment of pulmonary arterial hypertension (PAH) in patients with IPF before lung transplantation.Methods Between Sep.2002 and Aug.2010,lung transplantation (LTX) was performed on 96 patients with end-stage lung disease.Thirty patients with IPF were found to have PAH,as defined by mean pulmonary artery pressure (mPAP) ≥25 mm Hg by cardiac catheterization.Fifteen control patients (mPAP ＜25 mm Hg) were also identified.The diameter of the principal pulmonary artery (PPA) and ratio of main pulmonary artery to aortic diameter (rPA) were assessed by MSCT.Results MSCT-determined PPA and rPA were (34.4 ±4.4) mm and 1.03 ± 0.09 in patients with PAH,and (25.3 ± 3.3) mm (P＜0.01) and 0.77 ± 0.12(P＜0.01) in controls.In our group of patients,PPA (28.5 mm) had a sensitivity of 86.7％ and specificity of 80％ for predicting PAH,and rPA 0.935 had a sensitivity of 96.7％ and specificity of 93.3％ for predicting PAH.There was a correlation between the degree of PAH and PPA (r =861,P ＜0.01 ),and between the degree of PAH and rPA (r =0.887,P＜ 0.01 ) in patients with IPF associated with PAH.Conclusion MSCT is useful for the detection of IPF with PAH,and CT determined rPA has an excellent diagnostic value.
