Investigation in early-phase secretion function between islet α cells and β cells in subjects with normal glucose tolerance and family history of diabetes
10.3760/cma.j.issn.1000-6699.2012.04.009
- VernacularTitle:对有糖尿病家族史而糖耐量正常者胰岛α细胞和β细胞第一时相分泌功能的研究
- Author:
Xiaohui SUN
;
Ping SHI
;
Qingxia CHI
;
Luan WANG
;
Yuqin QI
;
Yangang WANG
- Publication Type:Journal Article
- Keywords:
Family history of diabetes;
Islet α cell;
Islet β cell;
Early phase function
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(4):290-292
- CountryChina
- Language:Chinese
-
Abstract:
To compare the early-phase secretion between islet α cells and β cells in subjects with normal glucose tolerance and to explore the influencing genetic factors on the function of islet cells.40 subjects with normal glucose tolerance and family history of diabetes ( FH+ ) and 55 healthy volunteers without family diabetes history ( FH ) were collected.Fasting and L-arginine stimulating insulin,glucagon,and tasting free fatty acid,as well as other indicators were determined in all subjects.Insulin resistance was evaluated by homeostasis model assessment for insulin resistance.After adjnsting for sex,age,and body mass index,the insulin secretion peak of the two groups reached both at two min,and began to decline at four min,the peak multiple of FH+group was significantly less than that of FH-group (7.29 vs 8.88,P＜0.05) ; glucagon secretion peak of both groups reached at two min and began to decline by four min.Fasting glucagon and peak multiple were not significantly different (P＞0.05) ; The ratio of fasting insulin to fasting glucagon of the two groups was without significantly difference ( P＞0.05 ).Under diabetes genetic background,the function of β cells decreases even in subjects with normal glucose tolerance.
