EMLA-ALK fusion gene in non-small cell lung cancer
10.3760/cma.j.issn.1673-422X.2012.03.016
- VernacularTitle:EML4-ALK融合基因阳性非小细胞肺癌
- Author:
Xiaolin HUANG
;
Ziang CAO
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Gene fusion;
Molecular diagnostic techniques
- From:
Journal of International Oncology
2012;39(3):212-214
- CountryChina
- Language:Chinese
-
Abstract:
EML4-ALK fusion gene can improve the expression of anaplastic lymphoma kinase (ALK) protein and activate ALK inducing tumor cells proliferation and anti-apoptosis.EMLA-ALK fusion gene in nonsmall-cell lung cancer which has unique clinical and pathological features is more common in young femal,never smokers,and adenocarcinoma patients,At present,EML4-ALK fusion gene can be detected using RT-PCR,FISH and IHC.Crizotinib,an ALK inhibitor,can block the gene's signal pathway and restrain tumor's activity.
