EZH2 gene and cancer
10.3760/cma.j.issn.1673-422X.2012.03.007
- VernacularTitle:EZH2与肿瘤的关系
- Author:
Jie BAI
;
Xiaoming SHUAI
;
Kaixiong TAO
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Therapy;
EZH2
- From:
Journal of International Oncology
2012;39(3):182-186
- CountryChina
- Language:Chinese
-
Abstract:
EZH2 is the catalytic subunit of polycomb repressive complex 2 (PRC2),which represses gene expression by catalyzing lysine 27 of histone H3.It is overexpressed in prostate cancer,breast cancer,bladder cancer,gastric cancer and several other cancers.There is a close correlation between overexpression of EZH2 and progression of malignancy,invasion and migration of cancer cells.With a thorough understanding of the function,up and down stream regulatory mechanism and clinicopathological features,EZH2 will be expected to as a target and provide a new way for the treatment of cancers.
